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Author Notes:
Department of Chemistry, Winship Cancer Institute, Emory University, Atlanta, USA E-mail: njui@emory.edu
We gratefully acknowledge Prof. Huw Davies for generous access to instrumentation and chemicals.
Subjects:
Research Funding:
Financial support was provided by Emory University and Winship Cancer Institute.
A mild catalytic system for radical conjugate addition of nitrogen heterocycles
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Abstract:
The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.
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© The Royal Society of Chemistry 2017
This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/).
