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Author Notes:

Correspondence to Colleen F. Kelley MD, MPH, The Hope Clinic of Emory University, 500 Irvin Court, Suite 200, Decatur, GA 30030, USA. Tel: +404 727 2134; e-mail: colleen.kelley@emory.edu

CFK conceived the study, recruited and enrolled human subjects, collected the specimens, analyzed the data, and wrote the manuscript.

LL, CI, SK, KP performed assays and analyzed the data.

MJM collaborated on the human subjects protocol and critically edited the research letter.

VCM and PSS provided guidance throughout the study and critically edited the research letter.

RRA oversaw the conduct of laboratory assays, provided guidance throughout the study, wrote and critically edited the research letter.

We would like to thank the CFAR Immunology and Pre-Clinical Virology Core Laboratories for assistance in conducting assays.

Conflict of interest: The authors report no conflict of interest.

Subjects:

Research Funding:

This work was supported by the National Institutes of Health: KL2TR000455 (to CFK), K23AI108335 (to CFK), R01MH085600 (to PSS), R37AI112787 (to RRA), the Georgia Research Alliance (MJM), Action Cycling Atlanta (MJM), The Atlanta Clinical and Translational Science Institute UL1TR000454, National Center for Research Resources P51RR169, the Office of Research Infrastructure Programs/OD P51OD11107, and the Emory Center for AIDS Research P30 AI050409.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases
  • Virology
  • SIMIAN IMMUNODEFICIENCY VIRUS
  • α4β7 integrin
  • RACIAL DISPARITIES
  • INFECTION
  • TRANSMISSION
  • SIV

Differences in expression of gut-homing receptors on CD4(+) T cells in black and white HIV-negative men who have sex with men

Tools:

Journal Title:

AIDS

Volume:

Volume 30, Number 8

Publisher:

, Pages 1302-1308

Type of Work:

Article | Post-print: After Peer Review

Abstract:

HIV incidence rates are higher among black men who have sex with men (BMSM) as compared with MSM of other race/ethnicities in the USA. We found that blood memory CD4+ cells from BMSM express higher levels of α4β7, the gut-homing integrin, compared with white MSM. Higher expression of α4β7 on blood CD4+ cells correlated with higher percentage of proliferating CD4+ α4β7 + cells in rectal tissue suggesting increased trafficking of potential HIV target cells to rectal mucosa could increase HIV susceptibility among BMSM.

Copyright information:

© 2016 Wolters Kluwer Health, Inc. All rights reserved.

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