About this item:
475 Views | 599 Downloads
Author Notes:
Corresponding author. Sookyong Koh, MD, PhD, 2015 Uppergate Drive ECC 310, Atlanta, GA 30322, USA. sookyong.Koh@emory.edu
This work was completed at Ann & Robert H. Lurie Children’s Hospital of Chicago, the pediatric teaching hospital for Northwestern University Feinberg School of Medicine.
The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Subjects:
Research Funding:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by NIH/NINDS R01 NS073768 (SK).
Keywords:
- Early-onset seizures
- Epilepsy
- Malformations of cortical development
- Hemispherectomy
- Neuroinflammation
Brain Inflammation in an Infant With Hemimegalencephaly, Escalating Seizures, and Epileptic Encephalopathy
Abstract:
Hemimegalencephaly, a congenital brain malformation typically characterized by enlargement of one hemisphere, is frequently associated with intractable epilepsy. The authors report a case of a 12-month-old girl with hemimegalencephaly who underwent semiurgent hemispherectomy because of rapidly escalating seizures, arrested development, and associated encephalopathy. The brain tissue was examined and evaluated for neuroinflammation. Immunohistochemical analysis of the brain tissue revealed the presence of abundant activated CD68-positive microglia and reactive astrogliosis. Detection of active inflammatory changes in the brain of a patient with hemimegalencephaly complicated by intractable epilepsy suggests a potential role of ongoing brain inflammation in seizure exacerbation and epileptic encephalopathy.
Copyright information:
© 2016 The Author(s)
This is an Open Access work distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/).
