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Author Notes:
Correspondence to: Shan Ping Yu, M.D., Ph.D., spyu@emory.edu.
Author contributions: JHL wrote the original draft, JZ carried out the revision and SPY participated in original writing and finalized the paper.
Conflicts of interest: Authors claim no conflicts of interest related to this work.
Subject:
Research Funding:
This paper was supported by an American Heart Association (AHA) Postdoctoral Fellowship 15POST25680013 (JHL), NIH grants NS085568 (SPY), and a VA Merit grant RX000666 (SPY).
Keywords:
- Science & Technology
- Life Sciences & Biomedicine
- Cell Biology
- Neurosciences
- Neurosciences & Neurology
- stroke
- therapeutic hypothermia
- drug-induced hypothermia
- ischemia
- cell death
- inflammation
- FOCAL CEREBRAL-ISCHEMIA
- TRAUMATIC BRAIN-INJURY
- PHARMACOLOGICALLY INDUCED HYPOTHERMIA
- NEURAL STEM-CELLS
- DRUG-INDUCED HYPOTHERMIA
- FREE-RADICAL PRODUCTION
- NERVE GROWTH-FACTOR
- DAMAGE COOL AID
- MILD HYPOTHERMIA
- MODERATE HYPOTHERMIA
Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke
Abstract:
Stroke is a leading cause of disability and death, yet effective treatments for acute stroke has been very limited. Thus far, tissue plasminogen activator has been the only FDA-approved drug for thrombolytic treatment of ischemic stroke patients, yet its application is only applicable to less than 4-5% of stroke patients due to the narrow therapeutic window (< 4.5 hours after the onset of stroke) and the high risk of hemorrhagic transformation. Emerging evidence from basic and clinical studies has shown that therapeutic hypothermia, also known as targeted temperature management, can be a promising therapy for patients with different types of stroke. Moreover, the success in animal models using pharmacologically induced hypothermia (PIH) has gained increasing momentum for clinical translation of hypothermic therapy. This review provides an updated overview of the mechanisms and protective effects of therapeutic hypothermia, as well as the recent development and findings behind PIH treatment. It is expected that a safe and effective hypothermic therapy has a high translational potential for clinical treatment of patients with stroke and other CNS injuries.
Copyright information:
© 2017, Medknow Publications. All rights reserved.
This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0/).
