About this item:

418 Views | 495 Downloads

Author Notes:

Address correspondence to Jianming Tang, jtang@uab.edu.

For all acknowledgements, see final published article.

Subjects:

Research Funding:

This work, including the efforts of Eric Hunter, Paul A. Goepfert, and Jianming Tang, was funded by NIAID (R01 AI064060).

This work, including the efforts of Shabir Lakhi, was also funded in part by NITRP (FIC 2D43 TW001042).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Virology
  • CD4CD8 LYMPHOCYTE RATIO
  • HIGHLY PATHOGENIC SIV
  • EXTENDED HUMAN MHC
  • HIV-1 INFECTION
  • IMMUNE CONTROL
  • ANTIRETROVIRAL THERAPY
  • VIRAL LOAD
  • SOUTHERN AFRICA
  • HLA
  • TRANSMISSION

Dynamics and Correlates of CD8 T-Cell Counts in Africans with Primary Human Immunodeficiency Virus Type 1 Infection

Show all authors Show less authors

Tools:

Journal Title:

Journal of Virology

Volume:

Volume 90, Number 22

Publisher:

, Pages 10423-10430

Type of Work:

Article | Final Publisher PDF

Abstract:

In individuals with HIV-1 infection, depletion of CD4+ T cells is often accompanied by a malfunction of CD8+ T cells that are persistently activated and/or exhausted. While the dynamics and correlates of CD4 counts have been well documented, the same does not apply to CD8 counts. Here, we examined the CD8 counts in a cohort of 497 Africans with primary HIV-1 infection evaluated in monthly to quarterly follow-up visits for up to 3 years in the absence of antiretroviral therapy. Statistical models revealed that (i) CD8 counts were relatively steady in the 3- to 36-month period of infection and similar between men and women; (ii) neither geography nor heterogeneity in the HIV-1 set-point viral load could account for the roughly 10-fold range of CD8 counts in the cohort (P > 0.25 in all tests); and (iii) factors independently associated with relatively high CD8 counts included demographics (age ≤ 40 years, adjusted P=0.010) and several human leukocyte antigen class I (HLA-I) alleles, including HLAA* 03:01 (P=0.013), B*15:10 (P=0.007), and B*58:02 (P < 0.001). Multiple sensitivity analyses provided supporting evidence for these novel relationships. Overall, these findings suggest that factors associated with the CD8 count have little overlap with those previously reported for other HIV-1-related outcome measures, including viral load, CD4 count, and CD4/CD8 ratio.

Copyright information:

© 2016, American Society for Microbiology. All Rights Reserved.

Export to EndNote