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Author Notes:

Corresponding author: S. B. Blakey: sblakey@emory.edu

We gratefully acknowledge Dr John Bacsa and Dr Kenneth Hardcastle (Emory X-Ray Center) for assistance with X-ray structural analysis.

Subject:

Research Funding:

This research was supported by the NSF (CHE-1362502).

Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry

Tools:

Journal Title:

Chemical Science

Volume:

Volume 8, Number 1

Publisher:

, Pages 697-700

Type of Work:

Article | Final Publisher PDF

Abstract:

The first total synthesis of malagashanine, a chloroquine potentiating indole alkaloid, is presented. A highly stereoselective cascade annulation reaction was developed to generate the tetracyclic core of the Malagasy alkaloids. This chemistry is likely to be broadly applicable to the synthesis of other members of this stereochemically unique family of natural products.

Copyright information:

© The Royal Society of Chemistry 2016 This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/).

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