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Author Notes:

Address correspondence to: Dr. Huan-You Wang, Department of Pathology, University of California San Diego Health System, 3855 Health Sciences Drive, La Jolla, CA 92093-0987, USA. Tel: 858-822-2538; Fax: 858-822-1415; E-mail: hywang2@ucsd.edu; huw003@ucsd.edu

Conflict of interest: None

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • Pathology
  • t(14;22)(q32;q11)
  • K-deleting element
  • marginal zone B-cell lymphoma
  • systemic lupus erythematosus
  • NON-HODGKIN-LYMPHOMA
  • LYMPHOPROLIFERATIVE DISORDERS
  • MALIGNANCIES
  • EXPRESSION
  • REMISSION
  • LEUKEMIA
  • THERAPY
  • GENES

Nodal involvement by marginal zone B-cell lymphoma harboring t(14;22)(q32;q11) involving immunoglobulin heavy chain and light chain lambda as the sole karyotypically recognizable abnormality in a patient with systemic lupus erythematosus

Tools:

Journal Title:

International Journal of Clinical and Experimental Pathology

Volume:

Volume 7, Number 8

Publisher:

, Pages 5221-5231

Type of Work:

Article | Final Publisher PDF

Abstract:

Recurrent non-random balanced chromosomal translocation, usually involving the immunoglobulin heavy chain (IgH) gene or an immunoglobulin light chain gene and a proto-oncogene, which results in the overexpression of the latter under the control of an enhancer or promoter of the former, is a hallmark of many types of non-Hodgkin lymphoma (NHL) of B-cell origin. However, translocations between IgH and the immunoglobulin (Ig) light chain lambda gene (IgL), namely, a t(14;22)(q32;q11), have rarely been described in B-cell NHL. Herein we report the first case of marginal zone B-cell lymphoma harboring a t(14;22)(q32;q11) as its sole genetic abnormality in a patient with a 12-year history of systemic lupus erythematosus (SLE). Other interesting findings of this case include: 1) the neoplastic B-cells lack expression of both surface and cytoplasmic Ig light chain as revealed by flow cytometry and 2) monoclonal rearrangement of Ig light chain kappa (IgK) only due to k-deleting element (kde) recombination event. This case illustrates the necessity of utilizing a multi-modality approach in the diagnosis of B-cell NHL.

Copyright information:

© 2014 the copyright will be released by the publisher under the “Creative Commons Attribution Non- Commercial License”, enabling the unrestricted non-commercial use, distribution, and reproduction of the published article in any medium, provided that the original work is properly cited.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/).

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