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Author Notes:

Address correspondence to: Steffanie Sabbaj, PhD., 845 19th Street South, BBRB 554 Birmingham, AL 35294 Telephone: (205) 975-7612 Fax: (205) 975-6027, sabbaj@uab.edu

NS, YW, VYD and SS performed experiments; JT HLA-typed the samples, SS analyzed the data, PAG, EH & SS designed experiments and wrote the manuscript.

Disclosure of conflict of Interest: The authors have no competing financial interests.

Subjects:

Research Funding:

This work was supported by NIH grant AI064060 awarded to EH and a developmental program award from UAB Center for AIDS Research, P30 AI027767 awarded to SS.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases
  • allogeneic responses
  • T cells
  • cytotoxic T-cells
  • mixed lymphocyte reaction
  • HLA-B
  • HIV-1 transmission
  • CYTOTOXIC T-LYMPHOCYTES
  • CLASS-I
  • TYPE-1 TRANSMISSION
  • ALLELES
  • REPLICATION
  • SUPPRESSION
  • CONCORDANCE
  • WOMEN
  • ALLOANTIBODY
  • ASSOCIATION

Brief Report: Enhanced Allogeneic Cellular Responses to Mismatched HLA-B Antigens Results in More Efficient Killing of HIV Infected Cells

Tools:

Journal Title:

Journal of Acquired Immune Deficiency Syndromes

Volume:

Volume 71, Number 5

Publisher:

, Pages 493-497

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Epidemiologic studies have demonstrated that HIV-1 discordant couples who share HLA-B alleles were more likely to transmit HIV-1. These data lead us to hypothesize that individuals who match at both HLA-B alleles should have a reduced allogeneic response than those who are not matched. We observed diminished killing of CD4+ target cells only when HLA-B alleles were matched. We propose that for cell-associated HIV-1 transmission, the ability of the recipient to eliminate infected cells from a donor partner may be enhanced when HLA-B alleles are different between partners. These findings suggest a novel mechanism for protection against HIV infection.

Copyright information:

© 2015 Wolters Kluwer Health, Inc. All rights reserved.

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