About this item:

178 Views | 253 Downloads

Author Notes:

Sheila C Dollard, Email:sgd5@cdc.gov

SD contributed to study design and data analysis, supervised lab work, and was lead writer on paper.

HK contributed to study design, facilitated involvement of the clinic facilities and staff, and analysis.

KR contributed to study design, specimen transport, and laboratory testing.

JS contributed to statistical analysis and manuscript preparation.

MA contributed to study design, specimen transport, and laboratory testing.

JW contributed to study design, specimen transport, and laboratory testing.

SS contributed to study design and financial support.

MC contributed to design, financial support, statistical analysis, manuscript preparation.

TH contributed to study design, study protocol, IRB approval, analysis, manuscript preparation.

All authors read and approved the final manuscript.

The authors would like to thank the parents of the children in this study.

The authors declare that they have no competing interests.

Research Funding:

Funding was provided by the Centers for Disease Control and Prevention.

Keywords:

  • Adult
  • Antibodies, Viral
  • Antibody Affinity
  • Child
  • Child Day Care Centers
  • Child, Preschool
  • Cytomegalovirus
  • Cytomegalovirus Infections
  • Female
  • Humans
  • Immunoglobulin G
  • Infant
  • Male
  • Pregnancy
  • Viral Load
  • Virus Shedding

Cytomegalovirus viral and antibody correlates in young children

Tools:

Journal Title:

BMC Research Notes

Volume:

Volume 7, Number 1

Publisher:

, Pages 776-776

Type of Work:

Article | Final Publisher PDF

Abstract:

Background Young, healthy children shedding cytomegalovirus (CMV) in urine and saliva appear to be the leading source of CMV in primary infection of pregnant women. Findings We screened 48 children 6 months – 5 years old for CMV IgG and measured levels of CMV IgG, IgM and IgG avidity antibodies, frequency of CMV shedding, and viral loads in blood, urine, and saliva. Thirteen of the 48 children (27%) were CMV IgG positive, among whom 3 were also CMV IgM positive with evidence of recent primary infection. Nine of the 13 seropositive children (69%) were shedding 102-105 copies/ml of CMV DNA in one or more bodily fluid. Among seropositive children, low IgG antibody titer (1:20–1:80) was associated with the absence of shedding (p = 0.014), and enrollment in daycare was associated with the presence of CMV shedding (p = 0.037). Conclusions CMV antibody profiles correlated with CMV shedding. The presence of CMV IgM more often represents primary infection in children than in adults. Correlating antibodies with primary infection and viral shedding in healthy children adds to the understanding of CMV infection in children that can inform the prevention of CMV transmission to pregnant women.

Copyright information:

© Dollard et al.; licensee BioMed Central Ltd. 2014

This is an Open Access work distributed under the terms of the Creative Commons Attribution 2.0 Generic License (http://creativecommons.org/licenses/by/2.0/).

Creative Commons License

Export to EndNote