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Author Notes:

Email: wallingford@austin.utexas.edu

JMT, Acquisition of data, Analysis and interpretation of data, Drafting or revising the article, Contributed unpublished essential data or reagents.

MMR, Acquisition of data, Analysis and interpretation of data.

GJB, Analysis and interpretation of data, Contributed unpublished essential data or reagents.

SG, Acquisition of data.

EH, Acquisition of data.

HAA-lami, Acquisition of data.

BZY, Analysis and interpretation of data.

RDF, Acquisition of data.

CC, Acquisition of data.

SV, Drafting or revising the article.

KJL, Acquisition of data.

ST, Acquisition of data, Analysis and interpretation of data, Drafting or revising the article, Contributed unpublished essential data or reagents.

SERE, Analysis and interpretation of data, Drafting or revising the article.

JBW, Conception and design, Analysis and interpretation of data, Drafting or revising the article.

We thank D. Parichy and T. Arlson for critical reading.

The authors declare that no competing interests exist.

Subjects:

Research Funding:

National Institute of Dental and Craniofacial Research F32DE023272 to Jacqueline M Tabler.

National Institutes of Health R01HD073151 to Steven Vokes.

Howard Hughes Medical Institute to Roian Egnor, John B Wallingford.

National Institutes of Health R01HD085901 to John B Wallingford.

This work was supported by an NRSA to JT from the NIDCR (F32DE023272); funding to ST from the Institut Pasteur, Association Française contre le Myopathies, and Agence Nationale de la Recherche (Laboratoire d’Excellence Revive, Investissement d’Avenir; ANR-10-LABX-73); and NIH R01HD073151 to SAV and R01HD085901 to JBW SERE is supported by the Howard Hughes Medical Institute; JBW was once an early career scientist of the HHMI.

Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx

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Journal Title:

eLife

Volume:

Volume 6

Publisher:

, Pages e19153-e19153

Type of Work:

Article | Final Publisher PDF

Abstract:

Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus.

Copyright information:

© 2017, Tabler et al

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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