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Author Notes:

Address Correspondence to: Zachary Johnson, Email: zjohnso2@gmail.com, Postal: 954 Gatewood Dr., Yerkes National Primate Center, Emory University, Atlanta, GA 30329 USA

The authors would like to thank Lorra Mathews for her assistance in maintaining the prairie vole colony and Jamie LaPrairie for thoughtful discussions and comments on early drafts of this manuscript.

Subjects:

Research Funding:

This research was supported by NIH Grants R01MH096983, and 1P50MH100023 to LJY, and the Swedish Brain Foundation to HW. Additional funding was provided by the NIH Office of Research Infrastructure Programs/OD P51OD11132 to YNPRC

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Behavioral Sciences
  • Endocrinology & Metabolism
  • Pair bonding
  • Social attachment
  • Monogamy
  • Immediate-early gene
  • Social decision-making network
  • Functional connectivity
  • MALE SEXUAL-BEHAVIOR
  • PAIR BOND FORMATION
  • FUNCTIONAL CONNECTIVITY
  • MICROTUS-OCHROGASTER
  • SOCIAL-BEHAVIOR
  • C-FOS
  • POLYGAMOUS VOLES
  • REWARD SYSTEM
  • VASOPRESSIN
  • BRAIN

Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles

Tools:

Journal Title:

Hormones and Behavior

Volume:

Volume 79

Publisher:

, Pages 8-17

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Oxytocin (OT) is a deeply conserved nonapeptide that acts both peripherally and centrally to modulate reproductive physiology and sociosexual behavior across divergent taxa, including humans. In vertebrates, the distribution of the oxytocin receptor (OTR) in the brain is variable within and across species, and OTR signaling is critical for a variety of species-typical social and reproductive behaviors, including affiliative and pair bonding behaviors in multiple socially monogamous lineages of fishes, birds, and mammals. Early work in prairie voles suggested that the endogenous OT system modulates mating-induced partner preference formation in females but not males; however, there is significant evidence that central OTRs may modulate pair bonding behavior in both sexes. In addition, it remains unclear how transient windows of central OTR signaling during sociosexual interaction modulate neural activity to produce enduring shifts in sociobehavioral phenotypes, including the formation of selective social bonds. Here we re-examine the role of the central OT system in partner preference formation in male prairie voles using a selective OTR antagonist delivered intracranially. We then use the same antagonist to examine how central OTRs modulate behavior and immediate early gene (Fos) expression, a metric of neuronal activation, in males during brief sociosexual interaction with a female. Our results suggest that, as in females, OTR signaling is critical for partner preference formation in males and enhances correlated activation across sensory and reward processing brain areas during sociosexual interaction. These results are consistent with the hypothesis that central OTR signaling facilitates social bond formation by coordinating activity across a pair bonding neural network.

Copyright information:

© 2015 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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