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Author Notes:

Thomas Cash: Email: thomas.cash@choa.org

The authors acknowledge the Emory + Children's Pediatric Research Biostatistics Core for their assistance with this manuscript.

Research support was provided by Swim Across America and the Children's Healthcare of Atlanta Foundation/Scott Shockley Family.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Subjects:

Correlation of Ezrin Expression Pattern and Clinical Outcomes in Ewing Sarcoma

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Journal Title:

Sarcoma

Volume:

Volume 2017

Publisher:

Type of Work:

Article | Final Publisher PDF

Abstract:

Background. Ezrin is a membrane-cytoskeleton linker protein that has been associated with metastasis and poor outcomes in osteosarcoma and high-grade soft tissue sarcomas. The prognostic value of ezrin expression in Ewing sarcoma is unknown. Methods. The relationship between ezrin expression and outcome was analyzed in a cohort of 53 newly diagnosed Ewing sarcoma patients treated between 2000 and 2011. The intensity and proportion of cells with ezrin immunoreactivity were assessed in diagnostic tumor tissue using a semiquantitative scoring system to yield intensity and positivity scores for each tumor. Results. Ezrin expression was detected in 72% (38/53) of tumor samples. The proportion of patients with metastatic disease was equal in the positive and negative ezrin expression groups. There was no significant difference in the 5-year event-free survival (EFS) between patients with positive versus negative ezrin expression. Patients whose tumor sample showed high ezrin intensity had significantly better 5-year EFS when compared to patients with low/no ezrin intensity (78% versus 55%; P=0.03). Conclusions. Ezrin expression can be detected in the majority of Ewing sarcoma tumor samples. Intense ezrin expression may be correlated with a favorable outcome; however further investigation with a larger cohort is needed to validate this finding.

Copyright information:

© 2017 Thomas Cash et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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