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Author Notes:

Thomas Cash: Email: thomas.cash@choa.org

The authors acknowledge the Emory + Children's Pediatric Research Biostatistics Core for their assistance with this manuscript.

Research support was provided by Swim Across America and the Children's Healthcare of Atlanta Foundation/Scott Shockley Family.

The authors declare that there is no conflict of interests regarding the publication of this paper.


Correlation of Ezrin Expression Pattern and Clinical Outcomes in Ewing Sarcoma


Journal Title:



Volume 2017


Type of Work:

Article | Final Publisher PDF


Background. Ezrin is a membrane-cytoskeleton linker protein that has been associated with metastasis and poor outcomes in osteosarcoma and high-grade soft tissue sarcomas. The prognostic value of ezrin expression in Ewing sarcoma is unknown. Methods. The relationship between ezrin expression and outcome was analyzed in a cohort of 53 newly diagnosed Ewing sarcoma patients treated between 2000 and 2011. The intensity and proportion of cells with ezrin immunoreactivity were assessed in diagnostic tumor tissue using a semiquantitative scoring system to yield intensity and positivity scores for each tumor. Results. Ezrin expression was detected in 72% (38/53) of tumor samples. The proportion of patients with metastatic disease was equal in the positive and negative ezrin expression groups. There was no significant difference in the 5-year event-free survival (EFS) between patients with positive versus negative ezrin expression. Patients whose tumor sample showed high ezrin intensity had significantly better 5-year EFS when compared to patients with low/no ezrin intensity (78% versus 55%; P=0.03). Conclusions. Ezrin expression can be detected in the majority of Ewing sarcoma tumor samples. Intense ezrin expression may be correlated with a favorable outcome; however further investigation with a larger cohort is needed to validate this finding.

Copyright information:

© 2017 Thomas Cash et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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