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To whom correspondence should be addressed: Eric Ortlund. Tel.: 404-727-5014; Fax: 404-727-2738; E-mail: eortlun@emory.edu.
P. M. M., B. R. K., J. A. K., I. I., and E. A. O. participated in research design.
P. M.M., B. R. K., and J. A. K. conducted the experiments.
P. M. M., B. R. K., J. A. K., I. I., and E. A. O. performed data analysis.
P. M. M., B. R. K., J. A. K., I. I., and E. A. O. wrote or contributed to the writing of the manuscript.
The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
The atomic coordinates and structure factors (codes 4PLD and 4PLE) have been deposited in the Protein Data Bank (http://wwpdb.org/).
This work was supported by National Institutes of Health Grant RO1DK095750 from NIDDK (to E. A. O.), Grant R01GM110387 from NIGMS (to I. I.), and Emory-NIEHS Graduate and Postdoctoral Training in Toxicology Grant T32ES012870 (to P. M. M.), American Heart Association Predoctoral Grant 12PRE12060583, National Science Foundation CAREER Award MCB-1149521, and a Molecular Basis Diseases fellowship (to B. R. K.).
Computational resources were provided in part by National Science Foundation XSEDE Allocation CHE110042 and Allocation m1254 at the National Energy Research Scientific Computing Center supported by the United States Department of Energy Office of Science Contract DE-AC02-05CH11231.
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.