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Author Notes:

Correspondence: Raghu R. Seethala, Email: rseethala@bwh.harvard.edu

RS, PH, and JS contributed to the study design and concept. RS, MM, and JS contributed to analysis and interpretation of data.

RS, PH, IA, GF, PP, MM, SC, OG, and JS contributed to the writing and review.

All authors read and approved the final manuscript.

We thank the US Critical Illness and Injury Trials Group: Lung Injury Prevention Study for collaborating with us on this investigation (see “Appendix” for a listing of collaborating investigators and clinical centers).

The authors declare that they have no competing interests.



  • Acute lung injury
  • Acute respiratory distress syndrome
  • Fluid resuscitation
  • Pneumonia
  • Sepsis

Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients


Journal Title:

Annals of Intensive Care


Volume 7, Number 1


, Pages 11-11

Type of Work:

Article | Final Publisher PDF


Background: Sepsis is a major risk factor for acute respiratory distress syndrome (ARDS). However, there remains a paucity of literature examining risk factors for ARDS in septic patients early in their course. This study examined the role of early fluid administration and identified other risk factors within the first 6 h of hospital presentation associated with developing ARDS in septic patients. Methods: This was a secondary analysis of septic adult patients presenting to the Emergency Department or being admitted for high-risk elective surgery from the multicenter observational cohort study, US Critical Injury and Illness trial Group-Lung Injury Prevention Study 1 (USCIITG-LIPS 1, NCT00889772). Multivariable logistic regression was performed to identify potential early risk factors for ARDS. Stratified analysis by shock status was performed to examine the association between early fluid administration and ARDS. Results: Of the 5584 patients in the original study cohort, 2534 (45.4%) met our criteria for sepsis. One hundred and fifty-six (6.2%) of these patients developed ARDS during the hospital stay. In multivariable analyses, Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR 1.10, 95% CI 1.07–1.13), age (OR 0.97, 95% CI 0.96–0.98), total fluid infused in the first 6 h (in liters) (OR 1.15, 95% CI 1.03–1.29), shock (OR 2.57, 95% CI 1.62–4.08), pneumonia as a site of infection (OR 2.31, 95% CI 1.59–3.36), pancreatitis (OR 3.86, 95% CI 1.33–11.24), and acute abdomen (OR 3.77, 95% CI 1.37–10.41) were associated with developing ARDS. In the stratified analysis, total fluid infused in the first 6 h (in liters) (OR 1.05, 95% CI 0.87–1.28) was not associated with the development of ARDS in the shock group, while there was an association in the non-shock group (OR 1.21, 95% CI 1.05–1.38). Conclusions: In septic patients, the following risk factors identified within the first 6 h of hospital presentation were associated with ARDS: APACHE II score, presence of shock, pulmonary source of infection, pancreatitis, and presence of an acute abdomen. In septic patients without shock, the amount of fluid infused during the first 6 h of hospital presentation was associated with developing ARDS.

Copyright information:

© 2017, The Author(s).

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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