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Author Notes:

Jennifer Gladys Mulle. Email: jmulle@emory.edu

Thanks to David Cutler for manuscript suggestions.

Subjects:

Research Funding:

This work was supported by NIH grant MH100917(JGM).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Genetics & Heredity
  • Schizophrenia genetics
  • Psychiatric genetics
  • Copy number variation
  • GWAS
  • LONG-TERM POTENTIATION
  • COPY-NUMBER VARIATION
  • GENOME-WIDE ASSOCIATION
  • X MENTAL-RETARDATION
  • DE-NOVO MUTATIONS
  • MAJOR PSYCHIATRIC-DISORDERS
  • 22Q11.2 DELETION SYNDROME
  • WILLIAMS-BEUREN-SYNDROME
  • NMDA RECEPTORS
  • BIPOLAR DISORDER

New discoveries in schizophrenia genetics reveal neurobiological pathways: A review of recent findings

Tools:

Journal Title:

European Journal of Medical Genetics

Volume:

Volume 58, Number 12

Publisher:

, Pages 704-714

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Schizophrenia research has undergone a recent transformation. By leveraging large sample sizes, genome-wide association studies of common genetic variants have approximately tripled the number of candidate genetic loci. Rare variant studies have identified copy number variants that are schizophrenia risk loci. Among these, the 3q29 microdeletion is now known to be the single largest schizophrenia risk factor. Next-generation sequencing studies are increasingly used for rare variant association testing, and have already facilitated identification of large effect alleles. Collectively, recent findings implicate voltage-gated calcium channel and cytoskeletal pathways in the pathogenesis of schizophrenia. Taken together, these results suggest the possibility of imminent breakthroughs in the molecular understanding of schizophrenia.

Copyright information:

© 2015 Elsevier Masson SAS. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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