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Author Notes:

Corresponding Author: Lara Boyd, PT, PhD, University of British Columbia, Department of Physical Therapy, 212-2177 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 1Z3, Tel: 01-604-827-3369, lara.boyd@ubc.ca.

Subjects:

Research Funding:

This work was supported by funding from the Canadian Institutes for Health Research (MOP-106651; PI: L.A.B).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • Stroke
  • human
  • metabolite
  • motor function
  • cortical thickness
  • MAGNETIC-RESONANCE-SPECTROSCOPY
  • INDUCED MOVEMENT THERAPY
  • HUMAN CEREBRAL-CORTEX
  • HUMAN BRAIN
  • SURFACE RECONSTRUCTION
  • GEOMETRICALLY ACCURATE
  • RECOVERY
  • MRI
  • SEGMENTATION

Cortical thickness and metabolite concentration in chronic stroke and the relationship with motor function

Tools:

Journal Title:

Restorative Neurology and Neuroscience

Volume:

Volume 34, Number 5

Publisher:

, Pages 733-746

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Introduction: Hemiparesis is one of the most prevalent chronic disabilities after stroke. Biochemical and structural magnetic resonance imaging approaches may be employed to study the neural substrates underpinning upper-extremity (UE) recovery after chronic stroke. Objective: The purposes of this study were to 1) quantify anatomical and metabolic differences in the precentral gyrus, and 2) test the relationships between anatomical and metabolic differences, and hemiparetic arm function in individuals in the chronic stage of stroke recovery. Our hypotheses were: 1) the Stroke group would exhibit reduced precentral gyrus cortical thickness and lower concentrations of total N-acetylaspartate (tNAA) and glutamate+glutamine (Glx) in the ipsilesional motor cortex; and 2) that each of these measures would be associated with UE motor function after stroke. Methods: Seventeen individuals with chronic (>6 months) subcortical ischemic stroke and eleven neurologically healthy controls were recruited. Single voxel proton magnetic resonance spectroscopy (H1MRS) was performed to measure metabolite concentrations of tNAA and Glx in the precentral gyrus in both ipsilesional and contralesional hemispheres. Surface-based cortical morphometry was used to quantify precentral gyral thickness. Upper-extremity motor function was assessed using the Wolf Motor Function Test (WMFT). Results Results demonstrated significantly lower ipsilesional tNAA and Glx concentrations and precentral gyrus thickness in the Stroke group. Ipsilesional tNAA and Glx concentration and precentral gyrus thickness was significantly lower in the ipsilesional hemisphere in the Stroke group. Parametric correlation analyses revealed a significant positive relationship between precentral gyrus thickness and tNAA concentration bilaterally. Multivariate regression analyses revealed that ipsilesional concentrations of tNAA and Glx predicted the largest amount of variance in WMFT scores. Cortical thickness measures alone did not predict a significant amount of variance in WMFT scores. Conclusions: While stroke impairs both structure and biochemistry in the ipsilesional hemisphere our data suggest that tNAA has the strongest relationship with motor function.
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