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Author Notes:

Corresponding author G.K. Pavlath: Emory University, Department of Pharmacology, 1510 Clifton Rd, Room 5027, Atlanta, GA 30322, USA. gpavlat@emory.edu.

M. E. Randolph: Conception and design, financial support, collection and assembly of data, data analysis and interpretation, manuscript writing, final approval of manuscript.

B. L. Phillips: Collection and assembly of data, data analysis and interpretation, manuscript writing, final approval of manuscript.

H. J. Choo: Collection and assembly of data, data analysis and interpretation, manuscript writing, final approval of manuscript.

K. E. Vest: Collection and assembly of data, data analysis and interpretation, manuscript writing, final approval of manuscript.

Y. Vera: Collection and assembly of data, data analysis and interpretation, final approval of manuscript.

G. K. Pavlath: Conception and design, financial support, administrative support, provision of study materials, data analysis and interpretation, manuscript writing, final approval of manuscript.

For acknowledgements, please see the full article.

The authors report no potential conflicts of interest.

Subjects:

Research Funding:

This work was supported by National Institute of Health grants AR061987 (GP) and DC012225 (MR).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Cell & Tissue Engineering
  • Biotechnology & Applied Microbiology
  • Oncology
  • Cell Biology
  • Hematology
  • Pharynx
  • Satellite cells
  • Myofiber
  • Myonuclear turnover
  • Muscle maintenance

Pharyngeal Satellite Cells Undergo Myogenesis Under Basal Conditions and Are Required for Pharyngeal Muscle Maintenance

Journal Title:

Stem Cells

Volume:

Volume 33, Number 12

Publisher:

, Pages 3581-3595

Type of Work:

Article | Post-print: After Peer Review

Abstract:

The pharyngeal muscles of the nasal, oral, and laryngeal pharynxes are required for swallowing. Pharyngeal muscles are preferentially affected in some muscular dystrophies yet spared in others. Muscle stem cells, called satellite cells, may be critical factors in the development of pharyngeal muscle disorders; however, very little is known about pharyngeal satellite cells (PSC) and their role in pharyngeal muscles. We show that PSC are distinct from the commonly studied hindlimb satellite cells both transcriptionally and biologically. Under basal conditions PSC proliferate, progress through myogenesis, and fuse with pharyngeal myofibers. Furthermore, PSC exhibit biologic differences dependent on anatomic location in the pharynx. Importantly, PSC are required to maintain myofiber size and myonuclear number in pharyngeal myofibers. Together, these results demonstrate that PSC are critical for pharyngeal muscle maintenance and suggest that satellite cell impairment could contribute to pharyngeal muscle pathology associated with various muscular dystrophies and aging.

Copyright information:

© 2015 AlphaMed Press.

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