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Author Notes:

Corresponding Author: Vin Tangpricha, MD, PhD, Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Center for Clinical and Molecular Nutrition, Nutrition & Health Sciences Program, Laney Graduate School, Emory University School of Medicine, and the Atlanta VA Medical Center, 101 Woodruff Circle NE–WMRB1301, Atlanta GA, 30322, USA. vin.tangpricha@emory.edu.

M. J. Lee, J. A. Alvarez, E. M. Smith, J. F. Chmiel, P. M. Joseph, R. E. Grossmann, A. Gaggar, T. R. Ziegler, and Vin Tangpricha contributed to the conception/design of the research.

M. J. Lee, J. A. Alvarez, J. F. Chmiel, P. M. Joseph, R. E. Grossmann, T. R. Ziegler, and V. Tangpricha contributed to the analysis and interpretation of the data.

A. Gaggar contributed to the acquisition and interpretation of the data.

M. J. Lee, J. A. Alvarez, E. M. Smith, and D. W. Killilea contributed to the acquisition, analysis, and interpretation of the data.

E. M. Smith contributed to the analysis of the data.

M. J. Lee, J. A. Alvarez, and V. Tangpricha drafted the manuscript.

M. J. Lee, J. A. Alvarez, E. M. Smith, D. W. Killilea, J. F. Chmiel, P. M. Joseph, R. E. Grossmann, A. Gaggar, T. R. Ziegler, and V. Tangpricha critically revised the manuscript.

M. J. Lee, J. A. Alvarez, E. M. Smith, D. W. Killilea, J. F. Chmiel, P. Joseph, R. Grossmann, A. Gaggar, T. R. Ziegler, and V. Tangpricha agree to be fully accountable for ensuring the integrity and accuracy of the work.

Subject:

Research Funding:

This work was supported by National Institutes of Health grants K01 DK102851 (J.A.A.), T32 DK007734 (E.M.S.), K24 DK096574 (T.R.Z.), the Atlanta Clinical and Translational Science Institute (UL1 TR000454) (T.R.Z., V.T.), and the CF Foundation TANGPR11A0 (V.T.).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Nutrition & Dietetics
  • micronutrients
  • cystic fibrosis
  • copper
  • iron
  • calcium
  • potassium
  • magnesium
  • sulfur
  • lung

Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis

Tools:

Journal Title:

Nutrition in Clinical Practice

Volume:

Volume 30, Number 6

Publisher:

, Pages 838-843

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Background: Patients with cystic fibrosis (CF) may be at risk for micronutrient depletion, particularly during periods of illness and infection. The purpose of this study was to investigate serum micronutrient status over time in adults with CF initially hospitalized with a pulmonary exacerbation. Materials and Methods: This was an ancillary study of a multicenter trial investigating the role of high-dose vitamin D supplementation in 24 adults with CF (mean age, 29.6 ± 7.3 years). We measured serum concentrations of copper (Cu), iron (Fe), calcium (Ca), magnesium (Mg), potassium (K), and sulfur (S) in subjects at the beginning of a pulmonary exacerbation and again at 3 months. Results: Serum concentrations of Cu, Fe, and Ca were significantly lower at baseline compared with 3 months following the pulmonary exacerbation (Cu: baseline, 1.5 ± 0.6 vs 3 months, 1.6 ± 0.6 μg/mL, P = .027; Fe: 0.8 ± 0.3 vs 1.3 ± 1.1 μg/mL, P = .026; Ca: 9.7 ± 0.8 vs 10.8 ± 2.0 mg/dL, P = .024). Serum concentrations of K, Mg, and S did not change over time (K: baseline, 4.9 ± 0.3 vs 3 months, 5.1 ± 0.5 mEq/L; Mg: 1.8 ± 0.2 vs 2.0 ± 0.3 mg/dL; S: 1288.6 ± 343 vs 1309.9 ± 290 μg/mL; P > .05 for all). Conclusion: Serum concentrations of Cu, Fe, and Ca increased significantly several months following recovery from acute pulmonary exacerbation in adults with CF. This may reflect decreased inflammation, improved food intake, and/or increased absorption following recovery.

Copyright information:

© 2015 SAGE Publications.

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