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Address correspondence to: Roberto Pacifici, M.D., Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, 101 Woodruff Circle, Room 1309, Atlanta, GA 30322, Telephone: 404-712-8420, Fax: 404-727-1300, roberto.pacifici@emory.edu.
PDA, FS, IB and GCI designed the human studies, performed the human research, and analyzed the human data.
RP, JYL and MNW designed the animal study/protocols.
YL, JR, LDW, CV, TL, AMT, MY, MR, and JA performed the animal research and analyzed the data.
RP wrote the manuscript and was the principle investigator.
We are grateful to Prof. L. Richiardi (University of Turin, Italy) for his assistance with the statistical analysis of the human data, Dr. Weinstein (NIH) for providing the Gas fl/fl mice and to Amgen, Inc for providing the IL-17RA−/− mice.
Disclosures: The authors state that they have no conflicts of interest.
This study was supported by grants from the National Institutes of Health (AR54625, DK007298 and RR028009).
JYL was supported by a grant from the National Institutes of Health (AR061453).
MNW was supported in part, by a grant from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development (5I01BX000105) and by NIH grants R01AR059364 and R01AG040013.
© 2015 Elsevier Inc.