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Author Notes:

Corresponding author: K.J. Ressler, Center for Behavioral Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd, Atlanta, GA 30329. Tel.: +(404) 727-7739; fax.: +(404) 727-8070. kerry.ressler@emory.edu.

Subjects:

Research Funding:

Funding for work in the Ressler lab was provided by the National Institutes of Mental Health (MH096764 to K.J.R.; F32MH090785 to G.M.G.).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Behavioral Sciences
  • Endocrinology & Metabolism
  • CRF
  • GABA
  • NMDA
  • Fear
  • Extinction
  • Amygdala
  • BNST
  • Anxiety
  • PTSD
  • r121919
  • MESSENGER-RNA EXPRESSION
  • CONDITIONED FEAR
  • RAT-BRAIN
  • MEMORY CONSOLIDATION
  • BASOLATERAL AMYGDALA
  • POTENTIATED STARTLE
  • ACOUSTIC STARTLE
  • D-CYCLOSERINE

GABA and NMDA receptors in CRF neurons have opposing effects in fear acquisition and anxiety in central amygdala vs. bed nucleus of the stria terminalis

Tools:

Journal Title:

Hormones and Behavior

Volume:

Volume 76

Publisher:

, Pages 136-142

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Beginning with Vale and Colleagues in 1981, corticotropin releasing factor (CRF) also called corticotropin releasing hormone (CRH) has repeatedly been identified as an important contributor to fear and anxiety behavior. These findings have proven useful to further our understanding of disorders that have significant fear-dysregulation, such as post-traumatic stress, as well as other stress- and anxiety-related disorders. Unfortunately, the data are not all in agreement. In particular the role of CRF in fear learning is controversial, with studies pointing to contradictory effects from CRF manipulation even within the same brain structure. Further, very few studies address the potentially promising role of CRF manipulation in fear extinction behavior. Here, we briefly review the role of CRF in anxiety, fear learning and extinction, focusing on recent cell-type and neurotransmitter-specific studies in the amygdala and bed nucleus of the stria terminalis (BNST) that may help to synthesize the available data on the role of CRF in fear and anxiety-related behaviors.

Copyright information:

© 2015 Published by Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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