Oxidative stress, inflammation, and markers of cardiovascular health

• Authors: Sindhu Lakkur, Emory University; Suzanne Judd, University of Alabama at Birmingham; Roberd Bostick, Emory University; William McClellan, Emory University; W. Dana Flanders, Emory University; Victoria Stevens, Emory University; Michael Goodman, Emory University
• Journal Title: Atherosclerosis
• Volume: Volume 243, Number 1
• Publisher: Elsevier | 2015-11-01, Pages 38-43
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.atherosclerosis.2015.08.032
• Subjects: Health Sciences, Epidemiology
• Keywords: Science & Technology; Life Sciences & Biomedicine; Cardiac & Cardiovascular Systems; Peripheral Vascular Disease; Cardiovascular System & Cardiology; Epidemiology; Oxidative stress; Inflammation; Lipoproteins; BALANCE SCORE; MYOCARDIAL-INFARCTION; COLORECTAL ADENOMAS; ALCOHOL-CONSUMPTION; RACIAL-DIFFERENCES; CIGARETTE-SMOKING; DIETARY PATTERN; SEX-DIFFERENCES; SERUM-ALBUMIN; RISK

Abstract

Objective: To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein-(LDL)-cholesterol, high-density lipoprotein-(HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood cell [WBC] counts) among 19,825 participants in a nationwide study. Methods: Using cross-sectional data 14 dietary and lifestyle components were incorporated into the OBS and the resulting score (range 3–26) was then divided into five equal intervals. Multivariable-adjusted odds ratios (ORs) for abnormal biomarker levels and 95% confidence intervals (CIs) were calculated using logistic regression models. Results: The ORs (95% CIs) comparing those in the highest relative to those in the lowest OBS equal interval categories were 0.50 (0.38–0.66) for CRP, 0.50 (0.36–0.71) for the total WBC count, and 0.75 (0.58–0.98) for LDL-cholesterol; all three p-values for trend were <0.001. The OBS-HDL-cholesterol association was statistically significantly inverse among females, but not among males. The OBS was not associated with serum albumin or triglycerides. Conclusion: Our findings suggest that an OBS may be associated with some, but not all, circulating lipids/lipoproteins and biomarkers of inflammation.