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Author Notes:

Address for reprints and corresponding author: Sheila T. Angeles-Han, MD, MSc, Division of Pediatric Rheumatology, Department of Pediatrics and Ophthalmology, Emory University, 2015 Uppergate Drive, Atlanta, GA 30307; Phone: 404-785-2000, Fax: 404-785-9096, sangele@emory.edu.

The authors would like to thank Drs. Amy Hutchinson, Phoebe Lenhart, Thomas JA Lehman and Kenneth Griffin for participating in the development of the previous versions of the EYE-Q.

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Eye Institute, the National Institute of Arthritis and Musculoskeletal and Skin Diseases or the National Institutes of Health.

Dr. Harrison is currently employed by Bristol-Myers Squibb and has stock in excess of $50K. However, all work presented in this manuscript was conducted outside her current employment and was not supported by Bristol-Myers Squibb.

The instrument used in this study, the Effects of Youngsters’ Eyesight on Quality of Life (EYE Q), can be licensed through Emory University but no royalties have been received by the authors.


Research Funding:

This study was supported by Award Number K23EY021760 from the National Eye Institute, the Arthritis Foundation New York Chapter, Weill Cornell Medical College Clinical and Translational Science Center (grant UL1RR024996), Emory Egleston Children's Research Center, the Knights Templar Eye Foundation, and also by the Career Development Bridge Funding Award from the American College of Rheumatology Research and Education Foundation and the Arthritis Foundation (Dr. Angeles-Han).

Dr. Prahalad is supported by The National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR060893), The Marcus Foundation Inc. and The Arthritis Foundation.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Rheumatology

Using the Effects of Youngsters' Eyesight on Quality of Life Questionnaire to Measure Visual Outcomes in Children With Uveitis

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Journal Title:

Arthritis Care and Research


Volume 67, Number 11


, Pages 1513-1520

Type of Work:

Article | Post-print: After Peer Review


Objective: The Effects of Youngsters’ Eyesight on Quality of Life (EYE-Q) is a novel measure of vision-related quality of life (QOL) and function in children. We aim to determine the validity of EYE-Q in childhood uveitis. Methods: We abstracted medical record data on arthritis and uveitis in a convenience sample of children with juvenile idiopathic arthritis (JIA) and/or uveitis. In addition to the EYE-Q, parents and patients completed questionnaires on overall QOL (Pediatric QOL Inventory - PedsQL), and physical functioning (Childhood Health Assessment Questionnaire - CHAQ). Results: Among 57 children (8 JIA, 24 JIA and uveitis, 25 uveitis alone), 102 ocular examinations were performed within 1 month of completing questionnaires. Uveitis patients had bilateral disease (69%), anterior involvement (78%), synechiae (51%) and cataracts (49%). Children with vision loss in their better eye (visual acuity (VA) 20/50 or worse) had worse EYE-Q (p = 0.006), and PedsQL (p = 0.028), but not CHAQ scores. The EYE-Q moderately correlated with logMAR VA (rs = −0.43), PedsQL (rs = 0.43) and CHAQ (rs = −0.45), but was not correlated with anterior chamber cells or intraocular pressure. The PedsQL and CHAQ did not correlate with VA or cells. There were strong correlations between the parent and child EYE-Q (rs = 0.62). Cronbach's α for the child report was 0.91. The EYE-Q had strong test-retest reliability (rs=0.75). Conclusion: The EYE-Q may be an important tool in the assessment of visual outcomes in childhood uveitis and an improvement over general measures in detecting changes in vision-related function.

Copyright information:

© 2015, American College of Rheumatology

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