About this item:

566 Views | 464 Downloads

Author Notes:

Corresponding author: Michael T. Compton, M.D., M.P.H., Lenox Hill Hospital, Department of Psychiatry, 111 E. 77th Street, New York, NY 10075. Tel: 212-434-3215. Fax: 212-434-3306. mcompton@nshs.edu.

The authors express gratitude to the participants involved in this study and the clinicians at the referral sites who identified eligible and interested patients.

The authors know of no conflicts of interest pertaining to this research.

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or National Institute of Mental Health.

Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.


Research Funding:

This work was supported by grant R01 MH081011 from the National Institute of Mental Health to the first author.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Psychiatry
  • Duration of untreated psychosis
  • First-episode psychosis
  • Negative symptoms
  • Personality
  • Positive symptoms
  • Psychosis
  • Schizophrenia
  • AXIS-V
  • DSM-IV

Personality domains, duration of untreated psychosis, functioning, and symptom severity in first-episode psychosis

Show all authors Show less authors


Journal Title:

Schizophrenia Research


Volume 168, Number 1-2


, Pages 113-119

Type of Work:

Article | Post-print: After Peer Review


Objectives: Early-course psychotic disorders have been extensively studied in terms of phenomenology, but little is known about the influence of personality traits on clinical features of first-episode psychosis. The aim of this study was to explore how the "big five" personality domains (neuroticism, extraversion, openness, agreeableness, and conscientiousness) are associated with treatment delay (duration of untreated psychosis, DUP), functioning, and positive and negative symptom severity. Methods: Data for these analyses were obtained from 104 participants enrolled from psychiatric inpatient units in Atlanta, Georgia, between August 2008 and March 2011. The NEO Five-Factor Inventory (NEO-FFI) was used to assess personality domains, and all other variables were measured in a standardized and rigorous manner using psychometrically sound instruments. Correlational analyses and multiple linear regressions were carried out to examine the strength of associations between variables of interest. Results: Findings indicated that except for openness, all the other personality variables contributed to some extent to the variance in DUP. Conscientiousness was positively correlated with functioning. Agreeableness was independently negatively associated with positive symptom severity and extraversion was independently negatively correlated with negative symptom severity. Conclusions: We report the first evidence suggesting that DUP is in part driven by personality domains. Functioning and symptom severity are also associated with those domains. Personality should be taken into account in order to better understand the phenomenology of early-course psychotic disorders as well as treatment-seeking behaviors.

Copyright information:

© 2015 Elsevier B.V.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Creative Commons License

Export to EndNote