Metabolic Characterization of the Common Marmoset (Callithrix jacchus) (vol 10, e0142916, 2015)

• Authors: Young-Mi Go Kang, Emory University; Yongliang Liang, Emory University; Karan Uppal, Emory University; Quinlyn A. Soltow, Emory University; Daniel E. L. Promislow, University of Washington; Lynn M. Wachtman, Harvard University; Dean P Jones, Emory University
• Journal Title: PLoS ONE
• Volume: Volume 11, Number 1
• Publisher: Public Library of Science | 2016-01-22, Pages e0147880-e0147880
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1371/journal.pone.0147880
• Subjects: Health Sciences, Pathology; Health Sciences, General
• Keywords: Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics

Abstract

This corrects the article "Metabolic Characterization of the Common Marmoset (Callithrix jacchus)" in volume 10, e0142916. High-resolution metabolomics has created opportunity to integrate nutrition and metabolism into genetic studies to improve understanding of the diverse radiation of primate species. At present, however, there is very little information to help guide experimental design for study of wild populations. In a previous non-targeted metabolomics study of common marmosets (Callithrix jacchus), Rhesus macaques, humans, and four non-primate mammalian species, we found that essential amino acids (AA) and other central metabolites had interspecies variation similar to intraspecies variation while non-essential AA, environmental chemicals and catabolic waste products had greater interspecies variation. The present study was designed to test whether 55 plasma metabolites, including both nutritionally essential and non-essential metabolites and catabolic products, differ in concentration in common marmosets and humans. Significant differences were present for more than half of the metabolites analyzed and included AA, vitamins and central lipid metabolites, as well as for catabolic products of AA, nucleotides, energy metabolism and heme. Three environmental chemicals were present at low nanomolar concentrations but did not differ between species. Sex and age differences in marmosets were present for AA and nucleotide metabolism and warrant additional study. Overall, the results suggest that quantitative, targeted metabolomics can provide a useful complement to non-targeted metabolomics for studies of diet and environment interactions in primate evolution.