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Author Notes:

Correspondence: Seth D Norrholm, Atlanta VA Medical Center, Mental Health Service Line, 1670 Clairmont Rd., MHSL 116A, Decatur, GA 30033-4098, USA. Tel +1-404-321-6111 (ext. 4722), Fax +1-404-417-2911, Email seth.norrholm@va.gov.

We thank Ilana Olin for her assistance in the preparation of this manuscript.

The authors report no conflicts of interest in this work.

Subjects:

Research Funding:

This work was supported by grants awarded to SDN from the Emory University Research Committee (Atlanta Clinical and Translational Science Institute), NARSAD, and the Department of Defense/Congressionally Directed Medical Research Program (CDMRP).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Clinical Neurology
  • Psychiatry
  • Neurosciences & Neurology
  • psychophysiology
  • pharmacotherapy
  • exposure therapy
  • pharmacogenetics
  • posttraumatic stress disorder
  • symptom clusters
  • REALITY EXPOSURE THERAPY
  • VIETNAM COMBAT VETERANS
  • SCRIPT-DRIVEN IMAGERY
  • COGNITIVE-PROCESSING THERAPY
  • CHILDHOOD SEXUAL-ABUSE
  • QUALITY-OF-LIFE
  • PSYCHOPHYSIOLOGICAL ASSESSMENT
  • NMDA RECEPTORS
  • FEAR-POTENTIATED STARTLE

Tailoring therapeutic strategies for treating posttraumatic stress disorder symptom clusters

Tools:

Journal Title:

Neuropsychiatric Disease and Treatment

Volume:

Volume 6

Publisher:

, Pages 517-532

Type of Work:

Article | Final Publisher PDF

Abstract:

According to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, posttraumatic stress disorder (PTSD) is characterized by three major symptom clusters following an event that elicited fear, helplessness, or horror. This review will examine each symptom cluster of PTSD separately, giving case study examples of patients who exhibit a preponderance of a given symptom domain. We use a translational approach in describing the underlying neurobiology that is relevant to particular symptoms and treatment options, thus showing how clinical practice can benefit from current research. By focusing on symptom clusters, we provide a more specific view of individual patient's clinical presentations, in order to better address treatment needs. Finally, the review will also address potential genetic approaches to treatment as another form of individualized treatment.

Copyright information:

© 2010 Norrholm and Jovanovic, publisher and licensee Dove Medical Press Ltd.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/).

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