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Author Notes:

Correspondence and requests for materials should be addressed to K.C.B. (email: kathleen.barnes@ucdenver.edu).

For author contributions and acknowledgements, please see the full article.

Competing interests: Nadia N. Hansel has a consulting relationship with GSK (Advisory Board). All other authors declare no competing financial interests.

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Research Funding:

Funding for this study was provided by National Institutes of Health (NIH) R01HL104608. Additional NIH funding includes NCI, R21CA178706 (R.D.H.), U01CA161032, P50CA125183 (O.O.), NCRR, G12RR003048 (G.M.D.), RR24975 (T.H.); NHGRI, R01HG007644, R21HG007233 (R.D.H.), R21HG004751 (H.R.J., J.G. and Z.S.Q.), T32HG000044 (C.R.G.); NHLBI, R01HL087699 (K.C.B.), R01HL118267 (L.K.W.), R01HL117004, R01HL088133, R01HL004464 (E.G.B.), HL081332, HL112656 (L.B.W.), R01HL69167, U01HL109164 (E.B. and D.M.), RC2HL101651, RC2HL101543, U01HL49596, R01HL072414 (C.O.), R01HL089897, R01HL089856, K01HL092601 (M.G.F.), R01HL51492, R01HL/AI67905 (J.G.F.), HHSN268201300046C, HHSN268201300047C, HHSN268201300048C, HHSN268201300049C, HHSN268201300050C (J.G.W.); NIAID, K08AI01582 (T.H.), R01AI079139 (L.K.W.), U19AI095230 (C.O.); NIEHS, R01ES015794 (E.G.B.); NIGMS, S06GM08016 (M.U.F.), T32GM07175 (C.R.G.); NIMHD, P60MD006902 (E.G.B.), 8U54MD007588, P20MD0066881 (M.G.F.); NSFGRF #1144247 (R.T.).

For complete funding information, please see the full article.

Keywords:

  • Science & Technology
  • Multidisciplinary Sciences
  • HISPANIC/LATINO POPULATIONS
  • CODING VARIATION
  • WIDE PATTERNS
  • ANCESTRY
  • HISTORY
  • INDIVIDUALS
  • MUTATIONS
  • Disease genetics
  • DNA sequencing
  • Genetic variation

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

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Journal Title:

Nature Communications

Volume:

Volume 7

Publisher:

, Pages 12522-12522

Type of Work:

Article | Final Publisher PDF

Abstract:

The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry.

Copyright information:

© 2016, The Author(s).

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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