About this item:

269 Views | 245 Downloads

Author Notes:

Email: wu.840@osu.edu

J.M.A., C.S.G., S.d.S., J.S.Y., Y.X. and L.W. designed the study and wrote the manuscript.

J.M.A., C.S.G., S.d.S., C.T., X.J. and C.S. performed the experiments and analyses.

J.M.A, C.S.G., S.d.S., J.S.Y., Y.X., B.K. and L.W. analyzed the data.

All authors discussed the data and approved the manuscript.

The authors thank N. Landau for the pLenti-puro plasmids, and J. Hach and S.H. Kim for technical assistance.

The antibody to HIV-1 p24 Gag (clone #24-2) and nevirapine were obtained from the NIH AIDS Reagent Program.

The authors declare no competing financial interests.

Subjects:

Research Funding:

This work was supported by NIH grants AI104483 and CA181997 (L.W.), AI114826 (J.S.Y.), AI102778 (Y.X.), AI120845 (X.J.) and AI049781 and GM104198 (B.K.).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology
  • Cell Biology
  • Medicine, Research & Experimental
  • Research & Experimental Medicine
  • DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE
  • CD4(+) T-CELLS
  • SAMHD1 RESTRICTS
  • NUCLEASE ACTIVITY
  • INFECTION
  • PHOSPHORYLATION
  • INHIBITION
  • PROTEIN
  • ACTIVATION
  • DGTP

SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

Tools:

Journal Title:

Nature Medicine

Volume:

Volume 22, Number 10

Publisher:

, Pages 1072-1074

Type of Work:

Article | Post-print: After Peer Review

Export to EndNote