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Correspondence and requests for materials should be addressed to S.J. (email: shibojiang@fudan.edu.cn) or K.L. (email: keliangliu55@126.com).
K.L. and S.J. conceived and supervised the project.
C.W. and X.L. performed design and synthesis.
F.Y., L.L., X.J., X.X., H.W., and L.Y. performed biological evaluation.
W.L., T.Z., and Z.Z. performed metabolic stability assessment.
C.W., K.L. and S.J. wrote the paper.
We thank Ms. Xiaoxia Yu at Institute of Biophysics, Chinese Academy of Sciences, and Dr. Baohua Zheng and Prof. Luhua Lai at the College of Chemistry and Molecular Engineering, Peking University for technical support for sedimentation equilibrium centrifugation.
The authors declare no competing financial interests.
This research was supported, in part, by grants from the National Natural Science Foundation of China (81373266, 81573266, 81501735 and 81361120378).
© 2016, The Author(s).