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Author Notes:

Correspondence should be addressed to K.S. (; Email: k.salaita@emory.edu)

Z.L. and Y.L. contributed equally to this work.

For author contributions and acknowledgments, see the full article.

Subjects:

Research Funding:

The authors are grateful for support from the US National Institutes of Health (R01-GM097399), the Alfred P. Sloan Research Fellowship, the Camille-Dreyfus Teacher-Scholar Award, the National Science Foundation (NSF) EAGER Award (1362113) and the NSF CAREER Award (1350829).

This research project was also supported in part by the Emory University Integrated Cellular Imaging Microscopy Core.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemical Research Methods
  • Biochemistry & Molecular Biology
  • AXIAL RESOLUTION
  • GOLD NANORODS
  • FORCE
  • TENSION
  • FLUORESCENCE
  • NANOPARTICLES
  • ADHESION
  • GROWTH
  • MODULATION
  • ACTIVATION

Nanoscale optomechanical actuators for controlling mechanotransduction in living cells

Journal Title:

Nature Methods

Volume:

Volume 13, Number 2

Publisher:

, Pages 143-+

Type of Work:

Article | Post-print: After Peer Review

Abstract:

To control receptor tension optically at the cell surface, we developed an approach involving optomechanical actuator nanoparticles that are controlled with near-infrared light. Illumination leads to particle collapse, delivering piconewton forces to specific cell surface receptors with high spatial and temporal resolution. We demonstrate optomechanical actuation by controlling integrin-based focal adhesion formation, cell protrusion and migration, and T cell receptor activation.

Copyright information:

© 2016 Nature America, Inc. All rights reserved.

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