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Email: pyyang@fudan.edu.cn Email: qlei@gudan.edu.cn These authors contributed equally to this work.
X.G. performed part of the experiments, analysed the data and co-wrote the manuscript.
F.R., J.T.L. and C.B.Y. assisted in doing the experiments, data analysis and proofreading the manuscript.
S.H.L., J.J.C., P.Y.Y. and S.X.J. contributed to GC–MS analysis of lipid pool and 1H-NMR spectra of acetate.
J.J.C., Y.W., G.Q.Y. and P.Y.Y. contributed to MS analysis.
H.B.Y. contributed to analysis of human hepatocarcinoma cancer samples and proofreading the manuscript.
D.W. and Y.Y.X. contributed to performing experiments and proofreading the manuscript.
Y.L. contributed to analysis of IHC samples.
J.C. and W.Q.Y. contributed to proofreading the manuscript.
S.H.L., Z.W.C. and P.Y.Y. contributed to design MS experiment and data analysis.
Q.Y.L. conceived the idea, designed and supervised the study, analysed the data and co-wrote the manuscript.
We thank the members of the Fudan Cancer Metabolism Laboratory for participation throughout this study.
We also thank Biomedical Core Facility, Fudan University for technical support.
The authors declare no competing financial interests.
This work was supported by MOST(2015CB910401 and 2013CB911201), NSFC (grant no. 81430057, 81225016, 31271454 and 21377106), Shanghai Key basic research program (12JC1401100), Scholar of ‘Dawn' Program of Shanghai Education Commission, Shanghai Outstanding Academic Leader (grant no. 13XD1400600), Cheung Kong Scholar's Program, and the Youth Science and Technology Leading Talent by MOST to Q.Y.L.
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