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Email: kressler@mclean@harvard.edu
A.P.W. formulated the research question, performed the data analysis and wrote the initial version of the paper. K.J.R. obtained funding, oversees the GTP study, contacted collaborators and revised the paper. All authors edited and commented on the manuscript.
G.G. provided consultant on the data analysis. B.B. contributed to conducting the GTP study. E.B.B. contributed to generating gene expression data. L.M.A. contributed to the genetic data analysis.
A.L. performed the genetic replication analysis in the Drakenstein cohort. A.C.B. and M.U. performed the gene expression replication analysis. J.J.S. performed and wrote the fMRI data analysis.
A.K.S. contributed to performing cell count estimate. T.K. performed the validation assays for DICER1 and miRNA expression and contributed to the design of the miRNA study.
D.J.S. and N.K. obtained funding, conducted the study, and obtained genetic data for the South African cohort.
A.E.A., K.C.K., D.E.W., M.U. and S.G. contributed to obtain funding and carrying out the DNHS. P.J. and Y.L. contributed to designing and conducting the miRNA study.
We appreciate the technical support of all of the staff and volunteers of the Grady Trauma Project, particularly Kimberly Kerley, BA, Jennifer Leveille, BA, Kristina Mercer, MS, Jordan Laird, BS, Allen W. Graham, BA, Angelo Brown and Claudia Klengel, MD.
We thank Charles Gillespie, MD/PhD, Ann Schwartz, MD and Tamara Weiss, MD for medical support, Divya Mehta, PhD for contributing to generation of gene expression data, Abigail Lott, PhD for maintaining the database.
Additionally, we thank Nirav Patel, MS, and Gregory Tharp, MS at the Emory Yerkes Genomics Core for technical support with the small RNA sequencing and data analysis.
We thank the participants of the Grady Trauma Project for their time and effort.
This study was supported in part by the Department of Veterans Affairs Career Development Award IK2CX000601 and the NARSAD Young Investigator Award (to A.P.W.). This work was primarily supported by the National Institutes of Mental Health (MH096764 and MH071537 to K.J.R.).
Support was also received from Emory and Grady Memorial Hospital General Clinical Research Center, National Institutes of Health (NIH). The Drakenstein study was funded by the Bill and Melinda Gates Foundation (1017641), the NIH (R21 MH098662) and the Medical Research Council (MRC) of South Africa. The DNHS was funded by DA022720 and RC1MH088283 (to A.E.A.).
T.K. is supported by a NARSAD YI Grant and an EMBO Long-Term Fellowship. The contents do not represent the views of the Department of Veterans Affairs or the United States Government.