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Author Notes:

Correspondence: hjxueren@126.com; zyzhou@nju.edu.cn

Li Zhu and Lijing Zhu contributed equally.

LZ and HS carried out the data analysis and drafted the manuscript; LJZ and HHW had significant roles in the data acquisition; LZ and LJZ performed the whole revision; JY and BRL are the oncologists responsible for all oncological support; WBC carried out the quality control of data and algorithms; XFY and TL had significant roles in the study design and manuscript review; JH and ZYZ formulated the research question, supervised the research program and edited the manuscript.

The authors declare that they have no competing interests.


Research Funding:

This work was supported by grants from National Natural Science Foundation of China (81371516, 81501441), Natural Science Foundation of Jiangsu Province (BK20150109), Six talent peaks project of Jiangsu Province (2015-WSN-079) and Jiangsu Provincial Health and Family Planning Commission Youth Scientific Research Project (Q201508). Go to:


  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • Intravoxel incoherent motion MR imaging
  • Tumor response
  • Magnetic resonance imaging
  • Cervical cancer
  • Concurrent chemo-radiotherapy

Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging

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Journal Title:

BMC Cancer


Volume 16, Number 1


, Pages 79-79

Type of Work:

Article | Final Publisher PDF


BACKGROUND: Intravoxel incoherent motion (IVIM) MR imaging has been applied in researches of various diseases, however its potential in cervical cancer patients has not been fully explored. The purpose of this study was to investigate the feasibility of IVIM MR imaging to monitor early treatment response in patients receiving concurrent chemo-radiotherapy (CCRT) for advanced cervical cancers. METHODS: Twenty-one patients receiving CCRT for advanced cervical cancer were prospectively enrolled. MR examinations including IVIM imaging (with 14 b values, 0 ~ 1000 s/mm(2)) were performed at 4 time points: 1-week prior to, 2-week and 4-week during, as well as immediately post CCRT (within 1 week). The apparent diffusion coefficient (ADC) maps were derived from the mono-exponential model, while the diffusion coefficient (D), perfusion fraction (f) and pseudo-diffusion coefficient (D*) maps were calculated from the bi-exponential model. Dynamic changes of ADC, D, f and D* in cervical cancers were investigated as early surrogate markers for treatment response. RESULTS: ADC and D values increased throughout the CCRT course. Both f and D* increased in the first 2 to 3 weeks of CCRT and started to decrease around 4 weeks of CCRT. Significant increase of f value was observed from prior to CCRT (f 1 = 0.12 ± 0.52) to two-week during CCRT (f 2 = 0.20 ± 0.90, p = 0.002). CONCLUSIONS: IVIM MR imaging has the potential in monitoring early tumor response induced by CCRT in patients with cervical cancers.

Copyright information:

© Zhu et al. 2016. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).

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