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To whom correspondence should be addressed: Sriharsa Pradhan. Tel: +1 978 380 7227; Fax: +1 978 921 1350; Email: pradhan@neb.com
Pierre-Olivier Estève and Guoqiang Zhang contributed equally to the paper as first authors.
We would like to thank Donald Comb, James V. Ellard, Rich Roberts, William Jack and Clotilde Carlow at New England Biolabs Inc., for research support and encouragement.
Conflict of interest statement: None declared.
RRBS data and RNA-seq data are available at Gene Expression Omnibus (GSE72860).
New England Biolabs Inc.; Cancer Prevention Research Institute of Texas [RP130432 to M.T.B.]; Center for Environmental and Molecular Carcinogenesis at MD Anderson; X.C.'s laboratory was supported by NIH [GM049245-22].
Funding for open access charge: New England Biolabs Inc.
© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.