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To whom correspondence should be addressed: E.A. Ortlund, Dept. of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322. Tel.: 404-727-5014; Fax: 404-727-2738; E-mail: eortlun@emory.edu.
We gratefully acknowledge Alexa Mattheyses, Jason Fritz, and Debby Martinson (Integrated Cellular Imaging Core, Emory University) and Shuiliang Yu (Case Western Reserve University) for training in microscopy methods, and Katie Doud (Case Western Reserve University) for generous assistance with the PPARβ/δ activation assays.
Data for 4LKP were collected at Southeast Regional Collaborative Access Team (SER-CAT) 22-BM beamline at the Advanced Photon Source, Argonne National Laboratory.
Use of the Advanced Photon Source was supported by the United States Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract W-31-109-Eng-38.
This work was supported, in whole or in part, by National Institutes of Health Grant R01 DK060684 and Grant P30CA138292 from the Emory University Integrated Cellular Imaging Microscopy Core of the Winship Cancer Institute comprehensive cancer center.
This work was also supported by start-up funds from Emory University (to E. A. O.).
E.H.A. was supported by National Institute of Health Graduate Training Grant 5T32GM008602 from Pharmacological Sciences, Emory University.
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.