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Author Notes:

Sidra Jahangir: pathoff@skm.org.pk; Asif Loya:asifloya@skm.org.pk; Momin T. Siddiqui: mtsiddi@emory.edu; Noreen Akhter: nakhter@skm.org.pk; Muhammed Aasim Yusuf: aasim@skm.org.pk

Each author acknowledges that final version of this study is read and approved by all authors.

This study was conducted with approval from Institutional Review Board (IRB) of both institutions associated with this study. All authors take responsibility to maintain relevant documentation in this respect.

No competing interests.

Subjects:

Keywords:

  • Cytology
  • endoscopic ultrasound
  • fine needle aspiration
  • neoplasm
  • pancreas

Accuracy of diagnosis of solid pseudopapillary tumor of the pancreas on fine needle aspiration: A multi-institution experience of ten cases.

Tools:

Journal Title:

CytoJournal

Volume:

Volume 12

Publisher:

, Pages 29-29

Type of Work:

Article | Final Publisher PDF

Abstract:

INTRODUCTION: Solid pseudopapillary tumor of the pancreas (SPTP) is a neoplasm of uncertain origin and indolent biologic behavior with distinctive morphological features occurring predominantly in young women. This tumor has an excellent prognosis compared to neuroendocrine and acinar cell carcinoma, which are close differential diagnoses based on morphology, hence making it crucial to diagnose SPTP correctly. OBJECTIVES: To discuss the cytomorphological features of 10 cases of SPTP reported in two institutions and to evaluate the diagnostic accuracy of endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) cytology in establishing the diagnosis of SPTP. METHODS: Ten diagnosed cases of SPTP were retrieved from the computerized endoscopy and pathology databases of our two tertiary care institutions. Nine patients had subsequent histological follow-up available. Eight patients underwent EUS-FNA while one patient each had ultrasound and computed tomography-guided FNA. The rapid on-site evaluation was carried out in all 10 cases, and additional material was retained for cell block preparation. Immunohistochemical (IHC) stains ranging from synaptophysin, progesterone receptor, chromogranin, β-catenin, CD10, and NSE were applied on cell blocks. Histological sections of all resected specimens were reviewed, and findings were correlated with those obtained by FNA. RESULTS: Adequate material was obtained in all ten cases. IHC stains helped to confirm the cytological impression of SPTP. Histological examination of resection specimens, available in 9/10 cases, confirmed the cytological diagnosis. CONCLUSIONS: FNA particularly that obtained with EUS guidance is an effective tool in the accurate diagnosis of SPTP.

Copyright information:

© 2015 Jahangir, et al.; Licensee Cytopathology Foundation Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0/).

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