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Correspondence to: Jing Chen (jchen@emory.edu), Hualiang Jiang (hljiang@mail.shcnc.ac.cn), or Chuan He (chuanhe@uchicago.edu).
C.H. conceived the project with H.J. and J.C., and J.W., C.Luo, C.S. and Q.Y. designed and performed most of the experiments.
J.L. and S.O. performed the virtual screening and bioinformatics analysis.
S.E., J.F. and H.K. assisted with the cell and mice experiments.
Y.Z. and H.L. assisted in the synthesis of the compounds.
J.L.V. and M.M. assisted in setting up the FRET-based compound screening, Y.W. and N.Z. conducted the NMR experimental and data analysis of DC_AC2 with Atox1.
C.Luan, H.D. and S.C. performed the SPR experiments for DC_AC50 with Atox1 and CCS.
C.H. and J.W. wrote the manuscript with input from H.J. and J.C.
We thank S. F. Reichard for help with editing the manuscript.
Competing financial interests: A patent application on DC_AC50 has been filed by the University of Chicago and the Shanghai Institute of Materia Medica.
This work was supported by grants from the National Natural Science Foundation of China (21210003 to H.J. and C.H., and 81230076, 91313000 to H.J.), the Hi-Tech Research and Development Program of China (2012AA020302 and 2012AA01A305 to C.L.), Chinese Academy of Sciences (XDA01040305 to C.L.), National Science Foundation (CHE-1213598 to C.H.) and National Institutes of Health (CA140515 to J.C.).
C.H. is supported by the Howard Hughes Medical Institute as an investigator.
© 2015 Macmillan Publishers Limited.