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Author Notes:

Address correspondence to: Dr. Xiangpeng Chu, People’s Hospital of Rizhao, 126 Taian Road, Donggang District, Rizhao 276826, Shandong, China. Tel: +86-18663058056; E-mail: redhotyouth@gmail.com

We thank Dr. Kayte Jenkin for excellent editing of the manuscript.

Disclosure of conflict of interest: None.



  • Lysophosphatidic acid receptor
  • autotaxin
  • lung diseases

Autotaxin-LPA receptor axis in the pathogenesis of lung diseases.


Journal Title:

International Journal of Clinical and Experimental Medicine


Volume 8, Number 10


, Pages 17117-17122

Type of Work:

Article | Final Publisher PDF


Lysophosphatidic acid (LPA) is a small lipid which mediates a variety of cellular functions via the activation of LPA receptors. LPA is generated from lysophosphatidylcholine by the extracellular enzyme, autotaxin (ATX). Elevated ATX expression, LPA production and their signaling pathways have been reported in multiple pathological conditions of lung tissue, including inflammation, fibrosis and cancer. Emerging evidence has highlighted the importance of ATX and LPA receptors in the pathogenesis of lung diseases. Here, we briefly review the current knowledge of different roles of the ATX-LPA receptor axis in lung diseases focusing on inflammation, fibrosis and cancer.

Copyright information:

© 2015 IJCEM

This is an Open Access work distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/).

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