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Author Notes:

Email Address: Xiangyu Guo: guosapphire@yahoo.com ; Xiao-Jiang : xli@emory.edu ;

All the authors (ZCT, WLY, XYG, XJL) contributed to the writing of the manuscript.

All authors read and approved the final manuscript.

We thank the Li lab members at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, for their input about Cas9-targeted monkeys and Cheryl Strauss for critical reading of this manuscript.

The authors declare that they have no competing interests.


Research Funding:

This work was supported by the National Key Basic Research Program of China (2012CBA01304), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13000000), and the State Key Laboratory of Molecular Developmental Biology, China.


  • CRISPR/Cas9
  • Non-human primates
  • Neurodegenerative diseases
  • Animal model

CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases


Journal Title:

Molecular Neurodegeneration


Volume 10, Number 1


Type of Work:

Article | Final Publisher PDF


Neurodegenerative diseases — Alzheimer’s disease(AD),Parkinson’s disease(PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and frontotemporal dementia (FTD) — are characterized by age-dependent and selective neurodegeneration. As the life expectancy of humans lengthens, there is a greater prevalence of these neurodegenerative diseases; however, the pathogenesis of most of these neurodegenerative diseases remain unclear, and we lack effective treatments for these important brain disorders.

Copyright information:

© Tu et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits making multiple copies, distribution, public display, and publicly performance, distribution of derivative works, provided the original work is properly cited. This license requires credit be given to copyright holder and/or author, copyright and license notices be kept intact.

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