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Author Notes:

Correspondence to: Maurizio Pompili, MD, PhD, Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital 1039, Via di Grottarossa, 1035, 00189 Rome, Italy. Email: maurizio.pompili@uniroma1.it. Telephone: +39-06-33775675. Fax: +39-06-33775342.

Serafini G and Pompili M contributed in reviewing the literature and drafting the paper.

Amore M and Girardi P provided the intellectual impetuous and supervised the search strategy.

Montebovi F, Erbuto D and Lamis DA provided help in selecting papers and drafting the papers.

The authors declare no conflict of interests.



  • Human immunodeficiency virus infection
  • Major depression
  • Quality of life
  • Suicidal behavior

Associations among depression, suicidal behavior, and quality of life in patients with human immunodeficiency virus


Journal Title:

World Journal of Virology


Volume 4, Number 3


, Pages 303-312

Type of Work:

Article | Final Publisher PDF


Aim: To investigate the potential associations among major depression, quality of life, and suicidal behavior in human immunodeficiency virus (HIV) patients. Methods: A detailed MEDLINE search was carried out to identify all articles and book chapters in English published from January 1995 to January 2015. Results: Based on the main findings, the prevalence of major depressive disorder (MDD) ranged from 14.0% to 27.2%. Furthermore, the prevalence of suicidal ideation varied from 13.6% to 31.0% whereas, attempted suicides were reported to range from 3.9% to 32.7%. Interestingly, various associated risk factors for both depression and suicide were identified in HIV patients. Finally, consistent associations were reported among MDD, suicidal ideation, and poor quality of life in individuals living with HIV. Conclusion: Although additional studies are needed to elucidate this complex association, our results suggest the importance of early detection of both MDD and suicidality in patients living with HIV.

Copyright information:

© The Author(s) 2015.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/).

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