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Author Notes:

Email Address: William M. Shafer : wshafer@emory.edu

We thank Jacqueline Balthazar for excellent technical assistance and Yaramah Zalucki for critical reading of early versions of the paper.

Subjects:

Research Funding:

This work was supported by NIH grants AI021150-29 (W.M.S.), AI42053 (A.E.J.), AI096788 (T.D.R., D. Dean, and R. Selden), and AI031496-22 (to P. F. Sparling, University of North Carolina) and a VA Merit Review Grant to W.M.S.

Overproduction of the MtrCDE Efflux Pump in Neisseria gonorrhoeae Produces Unexpected Changes in Cellular Transcription Patterns

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Journal Title:

Antimicrobial Agents and Chemotherapy

Volume:

Volume 59, Number 1

Publisher:

, Pages 724-726

Type of Work:

Article | Final Publisher PDF

Abstract:

The global consequence of drug efflux gene overexpression in bacteria has not been specifically analyzed because strains showing high-level expression typically have mutations in genes encoding regulatory proteins that control other genes. Results from a transcriptional profiling study performed with a strain of Neisseria gonorrhoeae that is capable of high-level transcription of the mtrCDE efflux pump operon independently of control by cognate regulatory proteins revealed that its overexpression has ramifications for systems other than drug efflux.

Copyright information:

© 2015, American Society for Microbiology

This is an Open Access work distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/).

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