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Author Notes:

Email Address: Andrea L. Crowell: andrea.crowell@emory.edu

Dr. Crowell has received funding from the American Psychiatric Association’s Psychiatric Research Fellowship Award funded by Eli Lilly and Company and the National Institutes of Health Loan Repayment Program.

Dr. Mayberg has received funding from the Dana Foundation, Woodruff Fund, Stanley Medical Research Institute, and the Hope for Depression Research Foundation and consulting and intellectual licensing fees from St. Jude Medical Inc.

All other authors report no commercial or financial relationships that could be construed as a potential conflict of interest.



  • deep brain stimulation
  • emotional reactivity
  • subcallosal cingulate
  • therapeutic course
  • treatment resistant depression

Characterizing the therapeutic response to deep brain stimulation for treatment-resistant depression: a single center long-term perspective.


Journal Title:

Frontiers in Integrative Neuroscience


Volume 9


, Pages 41-41

Type of Work:

Article | Final Publisher PDF


The number of depressed patients treated with deep brain stimulation (DBS) is relatively small. However, experience with this intervention now spans more than 10 years at some centers, with study subjects typically monitored closely. Here we describe one center's evolving impressions regarding optimal patient selection for DBS of the subcallosal cingulate (SCC) as well as observations of short- and long-term patterns in antidepressant response and mood reactivity. A consistent time course of therapeutic response with distinct behavioral phases is observed. Early phases are characterized by changes in mood reactivity and a transient and predictable worsening in self ratings prior to stabilization of response. It is hypothesized that this characteristic recovery curve reflects the timeline of neuroplasticity in response to DBS. Further investigation of these emerging predictable psychiatric, biological, and psychosocial patterns will both improve treatment optimization and enhance understanding and recognition of meaningful DBS antidepressant effects.

Copyright information:

© Copyright 2007-2015 Frontiers Media SA

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits distribution, public display, and publicly performance, distribution of derivative works, making multiple copies, provided the original work is properly cited. This license requires copyright and license notices be kept intact, credit be given to copyright holder and/or author.

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