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Author Notes:

Email Address: skugath@emory.edu

Conceived and designed the experiments: SK MEZ DJC. Analyzed the data: DJC MEZ DTO SK. Contributed reagents/materials/analysis tools: SK MEZ DJC.

Wrote the paper: DJC MEZ DTO LAD SK. Contributed samples and made critical revision of manuscript: SK LAD SP TW SLG MD RB WVC JR JM MS RK MP MBH NL D.

Mack D. Moulton MDK JFB AMG JE SDT BA DJK JSH PKRG. Acquired and processed data: AK JP PB KM DR YH.

Competing Interests: The authors have declared that no competing interests exist.

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Research Funding:

This work was funded by Crohn's & Colitis Foundation of America; Grant Number: CCFA1878 ]http://www.ccfa.org/] to SK.

Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.

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Journal Title:

PLoS ONE

Volume:

Volume 10, Number 6

Publisher:

, Pages e0128074-e0128074

Type of Work:

Article | Final Publisher PDF

Abstract:

The inflammatory bowel diseases (IBD) are common, complex disorders in which genetic and environmental factors are believed to interact leading to chronic inflammatory responses against the gut microbiota. Earlier genetic studies performed in mostly adult population of European descent identified 163 loci affecting IBD risk, but most have relatively modest effect sizes, and altogether explain only ~20% of the genetic susceptibility. Pediatric onset represents about 25% of overall incident cases in IBD, characterized by distinct disease physiology, course and risks. The goal of this study is to compare the allelic architecture of early onset IBD with adult onset in population of European descent.

Copyright information:

© 2015 Cutler et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits making multiple copies, distribution of derivative works, distribution, public display, and publicly performance, provided the original work is properly cited. This license requires copyright and license notices be kept intact, credit be given to copyright holder and/or author.

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