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Author Notes:

Email Address: medae@emory.edu

Special thanks are due to Dr. Michael Sendtner who provided the floxed BDNF mice used in this study.

Thanks are due to Drs. Francisco Alvarez, Jonathan Wolpaw, and Xiang Yang Chen who read and commented on earlier versions of this paper.

The author's names are listed in alphabetical order, except for Arthur W. English, not in any sense of relative contribution to this study.

The authors declare that there is no conflict of interests regarding the publication of this paper.


Research Funding:

This research project was supported in part by the Emory University Integrated Cellular Imaging Microscopy Core.

This work was supported by Grants NS057190 and HD032571 (Arthur W. English) and K12GM000680 (Jennifer C. Wilhelm) from the USPHS.

Neuronal BDNF Signaling Is Necessary for the Effects of Treadmill Exercise on Synaptic Stripping of Axotomized Motoneurons


Journal Title:

Neural Plasticity


Volume 2015


, Pages 392591-392591

Type of Work:

Article | Final Publisher PDF


The withdrawal of synaptic inputs from the somata and proximal dendrites of spinal motoneurons following peripheral nerve injury could contribute to poor functional recovery. Decreased availability of neurotrophins to afferent terminals on axotomized motoneurons has been implicated as one cause of the withdrawal. No reduction in contacts made by synaptic inputs immunoreactive to the vesicular glutamate transporter 1 and glutamic acid decarboxylase 67 is noted on axotomized motoneurons if modest treadmill exercise, which stimulates the production of neurotrophins by spinal motoneurons, is applied after nerve injury. In conditional, neuron-specific brain-derived neurotrophic factor (BDNF) knockout mice, a reduction in synaptic contacts onto motoneurons was noted in intact animals which was similar in magnitude to that observed after nerve transection in wild-type controls. No further reduction in coverage was found if nerves were cut in knockout mice. Two weeks of moderate daily treadmill exercise following nerve injury in these BDNF knockout mice did not affect synaptic inputs onto motoneurons. Treadmill exercise has a profound effect on synaptic inputs to motoneurons after peripheral nerve injury which requires BDNF production by those postsynaptic cells.

Copyright information:

© 2015 Joey Krakowiak et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License ( http://creativecommons.org/licenses/by/3.0/), which permits distribution, public display, and publicly performance, making multiple copies, distribution of derivative works, provided the original work is properly cited. This license requires credit be given to copyright holder and/or author, copyright and license notices be kept intact.

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