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Author Notes:

Correspondence Author:Email Address: lbernal@emory.edu

Jean L. Koff and Sampath Ramachandiran contributed to collecting, summarizing and writing the manuscript.

Leon Bernal-Mizrachi contributed to designing, writing and reviewing the manuscript.

The authors declare no conflict of interest.

Subjects:

Research Funding:

Leon Bernal-Mizrachi received funding from the Byron-Davis Hematology and Medical Oncology Research Fund.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Physical Sciences
  • Biochemistry & Molecular Biology
  • Chemistry, Multidisciplinary
  • Chemistry
  • NF-KAPPA-B
  • CHRONIC LYMPHOCYTIC-LEUKEMIA
  • BH3 MIMETIC ABT-199
  • MULTIPLE-MYELOMA
  • CELL-DEATH
  • COLON CANCERS
  • CYTOCHROME-C
  • BCL-2
  • GENE
  • FAMILY

A Time to Kill: Targeting Apoptosis in Cancer

Tools:

Journal Title:

International Journal of Molecular Sciences

Volume:

Volume 16, Number 2

Publisher:

, Pages 2942-2955

Type of Work:

Article | Final Publisher PDF

Abstract:

The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy.

Copyright information:

© 2015 by the authors

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits distribution of derivative works, distribution, public display, and publicly performance, making multiple copies, provided the original work is properly cited. This license requires copyright and license notices be kept intact, credit be given to copyright holder and/or author.

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