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Author Notes:

Address correspondence to Eileen M. Burd, Email: eburd@emory.edu.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Microbiology
  • MICROBIOLOGY
  • PENICILLIN-BINDING PROTEINS
  • BETA-LACTAM RESISTANCE
  • BORDERLINE SUSCEPTIBILITY
  • METHICILLIN RESISTANCE
  • EVOLUTION
  • GENE

Development of Oxacillin Resistance in a Patient with Recurrent Staphylococcus aureus Bacteremia

Tools:

Journal Title:

Journal of Clinical Microbiology

Volume:

Volume 52, Number 8

Publisher:

, Pages 3114-3117

Type of Work:

Article | Final Publisher PDF

Abstract:

Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.

Copyright information:

© 2014, American Society for Microbiology. All Rights Reserved.

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