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Author Notes:

Corresponding author: Otis Smart. Fax: 1-404-712-8576. Email: osmart@emory.edu

The authors thank Dr. Klaus Mewes for his assistance with the neuroimaging and intraoperative procedures.

None of the authors has any conflict of interest to disclose. This research was conducted in accordance with the policy and ethics of this journal. None of the work in this manuscript has been previously presented or published.


Research Funding:

The Emory University Neuroscience Initiative Fellowship (O.S.)

The National Institute of General Medical Sciences (NIGMS) Institutional Research and Academic Career Development Award (5K12GM000680-07) (O.S.)

The National Institute of Neurological Disorders and Stroke (NINDS) Ruth L. Kirschstein National Research Service Award (NS060392) (J.D.R.)

A fellowship in translational research (NS007480) (J.D.R.)

A career-development award (NS046322) (R.E.G.)

An additional grant (NS054809) (R.E.G.)

The Wallace H. Coulter Foundation

The Epilepsy Research Foundation


  • Electrocorticography
  • Epilepsy
  • Laterality
  • Neurostimulation
  • Seizure
  • Shifting

Hippocampal seizure-onset laterality can change over long timescales: A same-patient observation over 500 days


Journal Title:

Epilepsy and Behavior Case Reports


Volume 1, Number 1


, Pages 56-61

Type of Work:

Article | Final Publisher PDF


This study describes seizure laterality and localization changes over 500 consecutive days in a patient with bilateral temporal lobe epilepsy (BTLE) and implanted NeuroPace RNS™ System. During a continuous two-year time period, the RNS™ device stored 54 hippocampal electrocorticography (ECoG) seizures, which we analyzed to determine their distribution and time variance across hippocampi. We report nonrandom long-term seizure laterality and localization variations, especially in the first 200. days postimplant, despite equivalent total seizure counts in both hippocampi. This case suggests that hippocampal seizures dynamically progress over extensive timescales.

Copyright information:

© 2013 The Authors

This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/).

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