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Author Notes:
E-mail peng.jin@emory.edu
We apologize to the researchers whose work is not cited due to space limitations. We thank Cheryl Strauss and Brittany Phillips for critical reading of this manuscript, and Yuanxiang Zhu for graphic illustrations.
Subjects:
Research Funding:
Work in the laboratory of P.J. was supported by the National Institutes of Health (NS051630, NS079625, MH102690, and HD073162), Simons Foundation, March of Dimes, and NARSAD.
B.Y. is supported by a post-doctoral fellowship from the National Ataxia Foundation.
Keywords:
- Science & Technology
- Life Sciences & Biomedicine
- Cell Biology
- Developmental Biology
- Genetics & Heredity
- CELL BIOLOGY
- DEVELOPMENTAL BIOLOGY
- GENETICS & HEREDITY
- neurogenesis
- epigenetics
- DNA modifications
- histone modifications
- noncoding RNAs
- NEURAL STEM-CELLS
- ADULT HIPPOCAMPAL NEUROGENESIS
- NUCLEAR RECEPTOR TLX
- DNA METHYLTRANSFERASES DNMT3A
- NEWLY GENERATED NEURONS
- CENTRAL-NERVOUS-SYSTEM
- HEMI-METHYLATED DNA
- GENE-EXPRESSION
- SELF-RENEWAL
- RADIAL GLIA
Unlocking epigenetic codes in neurogenesis
Abstract:
During embryonic and adult neurogenesis, neuronal stem cells follow a highly conserved path of differentiation to give rise to functional neurons at various developmental stages. Epigenetic regulation-including DNA modifications, histone modifications, and noncoding regulatory RNAs, such as microRNA (miRNA) and long noncoding RNA (lncRNA)-plays a pivotal role in embryonic and adult neurogenesis. Here we review the latest in our understanding of the epigenetic regulation in neurogenesis, with a particular focus on newly identified cytosine modifications and their dynamics, along with our perspective for future studies. © 2014 Yao and Jin.
Copyright information:
© 2014 Yao and Jin;
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits making multiple copies, distribution, public display, and publicly performance, distribution of derivative works, provided the original work is properly cited. This license requires credit be given to copyright holder and/or author, copyright and license notices be kept intact. This license prohibits exercising rights for commercial purposes.
