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Author Notes:

E-mail: ygo@emory.edu E-mail: dpjones@emory.edu

Conceived and designed the experiments: YMG HJ DPJ. Performed the experiments: YMG DS HP WT SK MO HL DWK CWK LH. Analyzed the data: YMG DS DPJ. Contributed reagents/materials/analysis tools: HJ DPJ. Wrote the paper: YMG DPJ.

The authors have declared that no competing interests exist.

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Research Funding:

This work was supported by National Institutes of Health (NIH) grants HL113451, AG038746, ES009047 and ES023485. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Keywords:

  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • BONE MORPHOGENIC PROTEIN-4
  • NF-KAPPA-B
  • DEPENDENT REDOX REGULATION
  • FLUID SHEAR-STRESS
  • OXIDATIVE STRESS
  • BINDING-ACTIVITY
  • DNA-BINDING
  • GENE-EXPRESSION
  • IN-VITRO
  • GLUTATHIONE

Disturbed Flow Enhances Inflammatory Signaling and Atherogenesis by Increasing Thioredoxin-1 Level in Endothelial Cell Nuclei

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Journal Title:

PLoS ONE

Volume:

Volume 9, Number 9

Publisher:

, Pages e108346-e108346

Type of Work:

Article | Final Publisher PDF

Abstract:

Oxidative stress occurs with disturbed blood flow, inflammation and cardiovascular disease (CVD), yet free-radical scavenging antioxidants have shown limited benefit in human CVD. Thioredoxin-1 (Trx1) is a thiol antioxidant protecting against non-radical oxidants by controlling protein thiol/disulfide status; Trx1 translocates from cytoplasm to cell nuclei due to stress signaling, facilitates DNA binding of transcription factors, e.g., NF-κB, and potentiates inflammatory signaling. Whether increased nuclear Trx1 contributes to proatherogenic signaling is unknown.

Copyright information:

© 2014 Go et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits distribution of derivative works, distribution, public display, and publicly performance, making multiple copies, provided the original work is properly cited. This license requires copyright and license notices be kept intact, credit be given to copyright holder and/or author.

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