About this item:

744 Views | 0 Downloads

Author Notes:

Correspondence: Jonathan D. Glass, Department of Neurology, Emory University School of Medicine, Emory University, Atlanta GA. Email: jglas03@emory.edu.

The authors thank the patients and families of the Emory ALS clinic and the staff of the Emory ALS clinic, specifically Nicole Yarab, RN, and Meraida Polak, RN, BSN, for their assistance and contribution to the clinical database.

Content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

K. Traxinger and C. Richards report no disclosures.

Subjects:

Research Funding:

Supported in part by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR000454.

B.A. Johnson serves as a consultant for MANILA Consulting Group, Inc., and receives research support from the NIH (P30AI50409-14, R21ES020225-02, CA168930-01, and 60032445 [sub-contract with Northwestern University]) and from the US Department of Defense (IDEA Award PC093328).

R.H. Lyles receives salary/research support from the NIH (1 RC4 NR012527-01, 5 R01 ES012458-07, and 5 UL1RR025008-04).

J.D. Glass is author on a patent re: Ketoamide calpain inhibitors for peripheral neuropathy and receives research support from Neuralstem, Inc., the NIH (NINDS and NIA), the Packard Center for ALS Research, and the Muscular Dystrophy Association.

Prognosis and epidemiology of amyotrophic lateral sclerosis: Analysis of a clinic population, 1997–2011

Tools:

Journal Title:

Neurology: Clinical Practice

Volume:

Volume 3, Number 4

Publisher:

, Pages 313-320

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Amyotrophic lateral sclerosis is a disease with highly variable clinical features and prognosis. We analyzed the prognostic indicators of age, sex, bulbar or spinal onset, body mass index (BMI), and forced vital capacity (FVC) for 728 deceased patients from the Emory ALS Clinic. The median overall survival was 29.8 months from symptom onset, 15.8 months from diagnosis, and 14.3 months from the initial clinic visit. While univariate analyses revealed that each of the identified clinical features was strongly associated with patient survival, in multivariable analyses only age, BMI, and FVC measured at the first clinic visit were independent prognostic indicators; bulbar onset and sex were not significantly associated with survival prognosis after adjustment for the other clinical features.

Copyright information:

© 2013 American Academy of Neurology

Export to EndNote