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Author Notes:

Correspondence: Kevin D Bunting (kevin.bunting@emory.edu)

No potential conflicts of interest were disclosed.

Subjects:

Research Funding:

This work was supported by NIH R01DK059380, The Cure Childhood Cancer Foundation, The Rally Foundation for Childhood Cancer Research, and the Aflac Cancer and Blood Disorders Center (KD Bunting).

Keywords:

  • cytokine signaling
  • JAK-STAT
  • hematopoiesis
  • engraftment
  • quiescence
  • self-renewal
  • transplantation
  • stem cell

STAT5 in hematopoietic stem cell biology and transplantation

Tools:

Journal Title:

JAK-STAT

Volume:

Volume 2, Number 4

Publisher:

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Signal transducer and activator of transcription 5 (STAT5) regulates normal lympho-myeloid development through activation downstream of early-acting cytokines, their receptors, and Janus kinases (JAKs). Despite a general understanding of the role of STAT5 in hematopoietic stem cell (HSC) proliferation, survival, and self-renewal, the transcriptional targets and mechanisms of gene regulation that control multi-lineage engraftment following transplantation for the most part remain to be understood. In this review, we focus on the role of STAT5 in HSC transplantation and recent developments toward identifying the relevant downstream target genes and their role as part of a pleiotropic STAT5 mediated signaling response.

Copyright information:

© 2013 Landes Bioscience

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