STAT5 in hematopoietic stem cell biology and transplantation

• Authors: Zhengqi Wang, Emory University; Kevin Bunting, Emory University
• Journal Title: JAK-STAT
• Volume: Volume 2, Number 4
• Publisher: Landes Bioscience | 2013-10-01
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.4161/jkst.27159
• Subjects: Health Sciences, Medicine and Surgery; Biology, Physiology; Biology, Cell
• Keywords: cytokine signaling; JAK-STAT; hematopoiesis; engraftment; quiescence; self-renewal; transplantation; stem cell

Abstract

Signal transducer and activator of transcription 5 (STAT5) regulates normal lympho-myeloid development through activation downstream of early-acting cytokines, their receptors, and Janus kinases (JAKs). Despite a general understanding of the role of STAT5 in hematopoietic stem cell (HSC) proliferation, survival, and self-renewal, the transcriptional targets and mechanisms of gene regulation that control multi-lineage engraftment following transplantation for the most part remain to be understood. In this review, we focus on the role of STAT5 in HSC transplantation and recent developments toward identifying the relevant downstream target genes and their role as part of a pleiotropic STAT5 mediated signaling response.